Anti-MMP12 Antibody

This recombinant rabbit monoclonal antibody from Antibodies.com specifically targets MMP12 (matrix metalloproteinase 12, also known as macrophage elastase), a zinc-dependent endopeptidase involved in elastin degradation, extracellular matrix turnover, and macrophage-mediated tissue remodeling. Researchers apply it to study chronic obstructive pulmonary disease, emphysema, pulmonary inflammation, atherosclerosis, and tumor invasion in human, mouse, and rat model systems. The unconjugated antibody is supplied as 100 µl in a buffered solution of TBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. Validated applications include Western blot, immunocytochemistry and immunofluorescence, immunohistochemistry on paraffin sections, and flow cytometry, enabling flexibility across multiple experimental readouts. Aliquot the vial upon first thaw, store frozen at -20 °C in working volumes, and limit freeze-thaw cycles to preserve binding activity. Each lot is produced from a single rabbit clone, supporting consistent performance across experiments.