Anti-MMP-16 Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets MMP-16 (Matrix Metalloproteinase 16), also known as MT3-MMP, a membrane-anchored enzyme belonging to the matrix metalloproteinase family. The unconjugated reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit and is validated for western blot, immunohistochemistry, and ELISA workflows.

MMP-16 functions as a key mediator of pericellular proteolysis, cleaving extracellular matrix components and activating pro-MMP-2 (progelatinase A) to drive tissue remodeling, cell migration, and invasive behavior in tumor and stromal cells. Laboratory teams studying cartilage turnover, metastatic dissemination, angiogenesis, or developmental morphogenesis rely on anti-MMP-16 reagents to localize and quantify endogenous protein expression in cell lysates, conditioned media, and fixed tissue sections.

Reactivity has been verified against human, mouse, and rat samples, supporting translational research that bridges rodent disease models with human clinical specimens. The vial should be refrigerated, handled in small aliquots, and protected from repeated freeze-thaw cycles to preserve antibody performance across the shelf life of the reagent.