Anti-MLTK Antibody

Antibodies.com supplies a rabbit polyclonal antibody raised against MLTK (Mixed Lineage Kinase-like), a stress-responsive MAPKKK also known as ZAK that activates JNK and p38 MAPK signaling cascades. This unconjugated primary antibody is validated for Western blot, immunofluorescence, and ELISA applications, with confirmed reactivity against human and mouse samples, supporting studies of cellular stress, UV-induced apoptosis, and inflammatory signaling pathways.

The reagent is provided as 100 µl of polyclonal serum in an unconjugated format, allowing flexibility in downstream detection chemistries. Polyclonal clonality broadens epitope coverage of the target protein, which exists in human cells as a full-length ~800 amino acid isoform alongside a shorter ~454 amino acid variant. Experimental contexts include expression profiling in cell lines and primary tissue lysates, cytoskeletal regulation studies, and investigation of TGF-β and stress-activated kinase pathway dynamics.

Each preparation from Antibodies.com is produced under controlled immunization protocols and is intended for research use only. For best results, the antibody should be stored at -20 °C and protected from light to preserve activity across multiple freeze-thaw cycles. The product supports in vitro workflows and complements loss-of-function studies, co-immunoprecipitation experiments, and phospho-proteomic analyses targeting downstream JNK and p38 substrates.