Anti-MIF (R74) Antibody

Raised in rabbit and affinity-purified against Macrophage Migration Inhibitory Factor (MIF), this unconjugated polyclonal reagent from Antibodies.com targets a pleiotropic pro-inflammatory cytokine originally characterized for retaining macrophages at sites of inflammation and now recognized for its tautomerase enzymatic activity and counter-regulation of glucocorticoid-mediated immunosuppression. The antibody is supplied at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide as a preservative, at approximately pH 7.2, and is provided as a 50 µl aliquot that can be titrated into individual immunohistochemistry workflows. Validated for IHC on formalin-fixed tissue sections, the reagent shows reactivity with human, mouse, and rat samples, enabling comparative studies of cytokine distribution across species in inflamed tissues, tumor microenvironments, and immune cell infiltrates. MIF has been implicated in sepsis, rheumatoid arthritis, atherosclerosis, and multiple cancer types, so reliable tissue-based detection supports work in immunology, pathology, and translational research laboratories investigating cytokine signaling, glucocorticoid cross-talk, and disease-associated expression patterns.