Anti-mGluR-5 Antibody

Primary antibody reagents targeting metabotropic glutamate receptor 5 (mGluR5) enable neuroscience laboratories to interrogate excitatory glutamatergic signaling across cell and tissue models. This recombinant rabbit monoclonal antibody from Antibodies.com has been validated for western blot, immunocytochemistry with immunofluorescence, immunohistochemistry, and flow cytometry, and it detects the human, mouse, and rat orthologs of the receptor. Supplied as a 100 µl liquid vial in Tris-buffered saline at pH 7.4 with 1% BSA and 40% glycerol plus 0.05% sodium azide preservative, the unconjugated reagent couples readily to user-selected secondary antibodies and enzyme or fluorophore reporters. mGluR5 is a class C G protein-coupled glutamate receptor enriched in forebrain regions such as hippocampus, cortex, and striatum, where it tunes NMDA receptor activity, intracellular calcium mobilization, and long-term synaptic plasticity. Antibody use supports research into Fragile X syndrome models, Parkinson disease circuitry, addiction pathways, chronic pain mechanisms, and psychiatric disorder biology. For handling, refrigerate the vial and aliquot to limit freeze-thaw cycles that reduce binding titer.