Anti-mGluR-4 Antibody

A polyclonal antibody raised in rabbit against metabotropic glutamate receptor 4 (mGluR4) is offered by Antibodies.com for neuroscience and receptor biology research. The reagent is supplied as an unconjugated liquid in a 100 µl vial, suitable for western blot, immunohistochemistry, and ELISA workflows on human, mouse, and rat samples.

This polyclonal reagent targets mGluR4, a group III metabotropic glutamate receptor expressed in neurons of the cerebellum, thalamus, hippocampus, and other central nervous system regions, where it modulates presynaptic neurotransmitter release and inhibitory synaptic transmission. Researchers apply it in studies of L-DOPA-induced dyskinesia, Parkinson's disease models, anxiety circuits, and neuroprotective signaling cascades.

For western blot, the antibody is applied to membrane preparations from transfected cell lines or native brain tissue, producing a band near the expected molecular weight of the receptor. Immunohistochemistry protocols commonly employ the reagent on perfusion-fixed brain sections to map mGluR4 distribution in rodent and human tissue. The reagent is supplied as a liquid aliquot and should be stored refrigerated; small aliquots are recommended to limit freeze-thaw cycles and preserve antibody activity.