Anti-METTL1 Antibody

Raised in rabbit and validated for Western Blot detection of human methyltransferase-like 1, this polyclonal IgG primary antibody from Antibodies.com is supplied unconjugated at 200 µl per vial.

METTL1 (Methyltransferase Like 1) catalyzes the N7-methylguanosine (m7G) modification of tRNA in a complex with the WD repeat-containing protein WDR4, an epitranscriptomic mark linked to translational fidelity, stem-cell self-renewal, and oncogenic signaling in hepatocellular carcinoma and other malignancies. The antibody targets the human METTL1 protein and is intended for immunoblotting of cell lysates to study tRNA modification machinery, m7G methyltransferase activity, and downstream effects on protein synthesis.

Researchers investigating cancer biology, RNA epigenetics, and translation regulation will find this reagent useful for probing METTL1 expression across normal and tumor-derived human samples. The unconjugated IgG format supports downstream detection with HRP- or fluorescent-labeled secondary antibodies in standard Western Blot workflows, and the polyclonal nature provides broader epitope coverage for detecting the human target.