Anti-MET (phospho Y1349) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes the MET receptor tyrosine kinase only when phosphorylated at tyrosine 1349, a key autophosphorylation site within the kinase activation loop that recruits downstream adaptors such as GAB1 and GRB2. Supplied as 100 µL of unconjugated IgG, the reagent is validated for Western blot detection of phospho-MET in lysates from human, mouse, and rat samples. Because the epitope is the phospho-Y1349 residue, the antibody discriminates active signaling complexes from resting receptor pools, supporting pathway studies in cancer cell models where aberrant HGF/MET signaling drives proliferation, migration, and invasive growth. Researchers commonly pair this reagent with total MET antibodies and lambda phosphatase-treated controls to confirm phosphorylation specificity, and it works well with HRP-conjugated secondary detection on PVDF or nitrocellulose membranes.