Anti-MET (phospho Y1234) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes MET (also known as HGFR, hepatocyte growth factor receptor) when phosphorylated at tyrosine 1234. The reagent is unconjugated, of the IgG isotype, and supplied as a 200 µl liquid vial. It is validated for Western blot (WB) applications and reacts with human, mouse, and rat samples, supporting signaling studies across multiple model systems.

Phosphorylation of the MET activation loop at Y1234, paired with Y1235, is a key marker of receptor tyrosine kinase activation following HGF binding. Researchers use this antibody to probe ligand-induced signaling, downstream pathway engagement (PI3K/AKT, RAS/MAPK, and STAT3), and aberrant receptor activation in tumor samples. As a primary antibody, it pairs with anti-rabbit secondary reagents conjugated to HRP, fluorophores, or other reporters for chemiluminescent or fluorescent Western blot detection.

The polyclonal format offers broader epitope coverage than monoclonal alternatives, which can be useful when tracking dynamic phosphorylation states that may vary between sites. The unconjugated format allows laboratories to choose secondary detection chemistries matched to their existing imaging equipment, membrane substrates, and quantitative readouts.