Anti-MET (phospho Y1003) Antibody

Phosphorylation of the MET receptor tyrosine kinase at tyrosine 1003 (Y1003) controls ubiquitination and receptor turnover through the c-Cbl adaptor, making this site a focal point for studies of HGF/MET signalling. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com selectively recognizes the phospho-Y1003 epitope, allowing researchers to monitor MET downregulation following ligand stimulation or kinase inhibition. The antibody is validated for Western blot and immunofluorescence workflows and cross-reacts with human, mouse, and rat samples, supporting work in cell lines and primary tissues across multiple model systems. Provided as 200 µl of polyclonal antiserum, the reagent is applied in investigations of receptor internalization, downstream effector modulation, and pathway feedback within the broader MET signalling network.