Anti-Met Antibody

The Met proto-oncogene encodes the hepatocyte growth factor receptor (HGFR, also called c-MET), a receptor tyrosine kinase that drives proliferative, migratory, and invasive signaling downstream of HGF binding. Aberrant MET activation through gene amplification, exon-14 skipping mutations, or receptor overexpression has been reported across multiple carcinomas and is a frequent subject of oncology research and targeted-therapy development.

This rabbit polyclonal reagent from Antibodies.com is raised against the human Met protein and supplied unconjugated in a 50 µl vial. It is validated for Western blot and ELISA workflows and recognizes human MET, supporting studies of receptor expression, ligand-induced phosphorylation, and downstream pathway activity (including the PI3K/AKT and RAS/MAPK cascades) in cultured cell models. The polyclonal format presents multiple epitope specificities, which can be advantageous when probing distinct MET domains or detecting lower-abundance targets than a single monoclonal clone may reliably capture.

Recommended applications include Western blot analysis of cell lysates to monitor MET expression levels and ELISA-based quantification in compatible assay formats. For storage, refrigerate upon arrival, aliquot if needed to limit freeze-thaw cycles, and protect from light to preserve activity. For research use only.