Anti-MERTK Antibody [Assigned #A11341]

For cancer and immunology laboratories working on TAM receptor signaling, this unconjugated rabbit monoclonal reagent from Antibodies.com detects human MERTK with consistent specificity across multiple orthogonal readouts. The antibody is supplied as 100 µl of IgG in a single-use vial format, and it has been validated for western blot, immunohistochemistry, and immunoprecipitation applications on human samples.

MERTK is a single-pass transmembrane receptor tyrosine kinase that mediates efferocytosis — the engulfment of phosphatidylserine-displaying apoptotic cells — when activated by its vitamin K–dependent ligands GAS6 and Protein S. Aberrant MERTK signaling has been documented in cutaneous melanoma, where more than half of established cell lines overexpress the receptor relative to normal melanocytes, as well as in glioblastoma-associated macrophages, acute myeloid leukemia blasts, and the retinal pigment epithelium, where biallelic loss-of-function variants cause autosomal recessive retinitis pigmentosa. Downstream, ligand binding triggers MAPK/ERK, PI3K/AKT, and JAK/STAT cascades that influence tumor-cell survival, M2 macrophage polarization, and innate immune tolerance.

Recommended handling: store refrigerated, protect from light, and avoid repeated freeze-thaw cycles to preserve antibody activity. For research use only.