Anti-MEPCE Antibody

Raised in rabbit, this unconjugated polyclonal antibody from Antibodies.com targets human MEPCE (methylphosphate capping enzyme), the bifunctional enzyme responsible for N7-methylation of the 5' guanosine cap on nascent snRNAs and snoRNAs. Supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, the reagent is validated for western blotting, immunohistochemistry, and immunofluorescence workflows on human samples. MEPCE (also known as BCDIN3) stabilizes the trimethylguanosine cap structure that protects small non-coding RNAs from exonucleolytic decay, and altered MEPCE expression has been linked to defects in transcriptional regulation, snRNP biogenesis, and microcephalic primordial dwarfism. The 100 µl pack size supports multiple replicate blots and staining runs, and the polyclonal format increases the likelihood of recognizing multiple epitopes across the human protein. Store refrigerated at 4°C for short-term use or at -20°C for long-term storage, protected from light, and aliquot upon receipt to limit repeated handling.