Anti-MEK1 (phospho-S298) Antibody

Raised in rabbit as a polyclonal reagent, this phospho-specific antibody recognizes MEK1 only when serine 298 is phosphorylated, providing a tool for monitoring activation-state changes of the MAP2K1 kinase inside the MAPK/ERK signaling cascade. Distributed by Antibodies.com at 1 mg/mL and supplied as a 100 µL aliquot, the antibody is validated for Western blot detection of the phosphorylated target in lysates prepared from human, mouse, and rat samples.

S298 lies within a regulatory region of MEK1 and its phosphorylation is linked to ERK-driven negative feedback on the MAPK pathway, so the reagent helps researchers discriminate signal-active from signal-quiescent kinase across cell and tissue preparations. The product is provided in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotective stabilizer, a format suitable for storage at -20 °C with protection from light. Aliquoting on first use and limiting freeze-thaw cycles preserves phospho-specific binding activity across multiple experiments, while the unconjugated, polyclonal nature of the reagent gives flexibility for downstream western blot detection with standard secondary antibody systems.