Anti-MEK-6 Antibody

This polyclonal reagent from Antibodies.com targets MEK-6 (also known as MAP2K6 or MKK6), a dual-specificity protein kinase that phosphorylates and activates p38 MAP kinase (MAPK14) within the cellular stress response and inflammatory signaling cascades. Raised in rabbit, the antibody is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, shipped as a 100 µl aliquot suitable for routine laboratory workflows.

Validated applications include Western blot, immunohistochemistry, and immunofluorescence, with demonstrated reactivity against human, mouse, and rat samples. The unconjugated format allows flexible pairing with secondary antibodies of choice for chromogenic or fluorescence-based detection systems. MEK-6 acts as a key upstream activator in the p38 MAPK pathway, responding to environmental stressors, pro-inflammatory cytokines such as TNF-α and IL-1, and is implicated in immune cell signaling, apoptosis regulation, and cellular differentiation processes relevant to inflammation and cancer research.

For storage, keep the vial refrigerated at 4°C for short-term use, or freeze at -20°C in single-use aliquots to avoid repeated freeze-thaw cycles that may reduce antibody titer. The glycerol-containing buffer protects the immunoglobulin during frozen storage. This reagent is intended for research use only and is not approved for diagnostic or therapeutic applications.