Anti-MEK-1 Antibody

This rabbit polyclonal antibody targets MEK-1 (MAP2K1), a dual-specificity kinase that phosphorylates and activates ERK1/2 within the canonical RAS-RAF-MEK-ERK signaling cascade. The unconjugated reagent is supplied by Antibodies.com as a 100 µl vial and is validated for western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat sample backgrounds.

MEK-1 sits at a critical node in mitogenic signaling and is widely studied in oncology, developmental biology, and neuroscience research. Investigators use this reagent to probe pathway activation status, characterize small-molecule inhibitor responses in cell culture models, and assess expression patterns in fixed tissue sections. The polyclonal format allows recognition of multiple epitopes on the ~43 kDa target, which can be useful when working with post-translationally modified or mutant forms of the kinase, including those implicated in cardio-facio-cutaneous and Noonan-spectrum disorders where the pathway is constitutively active.

Handling recommendations: keep refrigerated, protect from light, and aliquot to limit freeze-thaw cycles. For research use only, not intended for diagnostic or therapeutic applications.