Anti-MEK-1 Antibody

Raised in rabbit, this unconjugated polyclonal reagent from Antibodies.com targets the dual-specificity kinase MEK-1 (also known as MAP2K1 or MKK1), an upstream activator of ERK1 and ERK2 within the canonical RAS-RAF-MEK-ERK mitogen-activated protein kinase cascade. Supplied as 100 µl of liquid antiserum, the antibody is validated for western blot detection of endogenous MEK-1 in human, mouse, and rat samples, and is also recommended for immunohistochemistry on formalin-fixed tissue sections and for ELISA-based assays. Because the reagent is unconjugated, it can be paired with the user's choice of HRP, biotin, or fluorescent secondary detection chemistries, and the polyclonal format provides broad epitope coverage that is useful when monitoring total MEK-1 expression alongside phosphorylation-state readouts. The antibody supports research into mitogenic and oncogenic signaling, mechanism-of-action studies with MEK pathway inhibitors, and characterization of pathway activation in cell biology and translational laboratory workflows, and is intended for research use only.