Anti-MEF2C (phospho-S396) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes MEF2C phosphorylated at serine 396, a key regulatory site on the myocyte enhancer factor 2C transcription factor. The reagent is supplied at 1 mg/ml in PBS buffer containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, with a total volume of 100 µl per vial.

MEF2C plays essential roles in cardiac, skeletal muscle, and neuronal development, where post-translational phosphorylation modulates its transcriptional activity and subcellular localization. The S396 phospho-site has been implicated in signaling pathways that govern myogenic differentiation, neuronal survival, and cardiac hypertrophy, making phospho-specific detection valuable for studies of these processes.

Validated for Western blot, immunohistochemistry, and immunofluorescence, the antibody has been tested on human, mouse, and rat samples, offering broad species coverage for cross-disciplinary research programs. The unconjugated format provides flexibility in downstream detection, allowing choice of secondary antibody and fluorophore or enzyme conjugate. Store at -20°C in working aliquots to preserve antibody activity and limit freeze-thaw cycles. For research use only.