Anti-MEF2A (Acetyl-K403) Antibody

This rabbit polyclonal antibody from Antibodies.com selectively recognizes myocyte enhancer factor 2A (MEF2A) when acetylated at lysine 403, a post-translational mark that modulates the transcription factor's DNA-binding activity and downstream gene programs. Provided in a 100 µl vial as unconjugated antibody at 1 mg/ml in phosphate buffered saline (pH 7.3) with 0.05% sodium azide, the reagent is validated for western blot detection of human, mouse, and rat samples.

MEF2A is a MADS-box transcription factor with established roles in skeletal and cardiac muscle differentiation, vascular smooth muscle gene regulation, and neuronal survival pathways. Acetylation at K403, dynamically controlled by acetyltransferases such as p300 and class IIa deacetylases, links MEF2A activity to calcium-dependent signaling, stress responses, and chromatin remodeling. Tracking this modification in cell lysates or tissue extracts allows researchers to monitor signal-dependent changes in MEF2A regulation alongside total protein levels.

The polyclonal format enriches recognition of the acetylated epitope while tolerating variation in flanking sequence, and the reagent pairs naturally with total MEF2A antibodies for side-by-side comparison of modified versus unmodified protein pools. Sodium azide at 0.05% serves as a preservative; gentle mixing before use helps maintain binding activity across repeated experiments.