Anti-MED12 Antibody

MED12 (Mediator Complex Subunit 12) is a key component of the Mediator complex, a multiprotein assembly that bridges transcription factors with RNA polymerase II to control gene expression. This rabbit polyclonal antibody from Antibodies.com targets MED12 and is validated for Western Blot (WB) applications across human, mouse, and rat samples, supporting cross-species comparative work in transcriptional regulation.

The unconjugated reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3, and is packaged in a 100 µl vial. The polyclonal format allows recognition of multiple epitopes on MED12, which is useful for detecting the protein in cell and tissue lysates. MED12 is implicated in the Wnt/β-catenin signaling pathway and has been linked to FG syndrome, Lujan syndrome, and several oncogenic processes, including breast cancer and uterine leiomyoma. Researchers in developmental biology, chromatin biology, and cancer signaling can apply this antibody to examine MED12 expression, its incorporation into the Mediator complex, and its functional interactions with regulatory partners.