Anti-MECR Antibody

MECR (mitochondrial enoyl-CoA reductase) is a nuclear-encoded enzyme that contributes to the type II fatty acid synthesis pathway in mitochondria, and the rabbit polyclonal antibody from Antibodies.com enables researchers to detect this protein by Western blot. Produced as an IgG preparation and supplied unconjugated in a 200 µl vial, the reagent is validated for detection of human MECR in cell lysates and tissue homogenates. MECR has been investigated in the context of mitochondrial lipid biosynthesis and inborn errors of mitochondrial lipid metabolism, including MECR-related neurodegenerative presentations involving dystonia and optic atrophy.

The polyclonal format targets multiple epitopes on MECR, which can help when lower-affinity monoclonal antibodies fail to detect the protein in a given preparation. Standard Western blot workflows typically pair the primary at 1-5 µg/ml with an HRP- or fluorophore-conjugated anti-rabbit IgG secondary, depending on the imaging system used. The unconjugated format gives laboratories flexibility to integrate the antibody into existing detection pipelines without changing secondary reagents.

For storage, keep the vial at -20 °C and divide into smaller aliquots to limit freeze-thaw cycles. Once thawed, keep the working aliquot refrigerated and avoid repeated freeze-thaw events to preserve antibody activity across multiple experiments.