Anti-MECP2 Antibody

MECP2 (Methyl-CpG-binding protein 2) is an X-linked transcriptional regulator that binds methylated CpG dinucleotides and is essential for mature neuronal function. Loss-of-function mutations are linked to Rett syndrome, while gene duplication causes MECP2 duplication syndrome, making reliable detection of this chromatin-associated protein central to neuroscience and epigenetics research. This rabbit polyclonal reagent from Antibodies.com was raised against MECP2 and recognizes the human target in Western blot, immunohistochemistry, and flow cytometry workflows. Supplied as 200 µl of unconjugated IgG, the antibody supports studies of neuronal gene silencing, synaptic maturation, and neurodevelopmental disease models. Researchers characterizing post-mitotic neurons, glial chromatin states, and iPSC-derived cortical cultures use this reagent to visualize endogenous MECP2 expression in tissue sections and isolated cell populations. For handling, refrigerate the vial upon arrival, aliquot to limit freeze-thaw cycles, and protect from light to preserve antibody activity across multiple experiments.