Anti-MECP2 Antibody

A polyclonal antibody raised in rabbit that recognizes human methyl-CpG binding protein 2 (MECP2) is offered by Antibodies.com for research applications. MECP2 is a transcriptional regulator that binds methylated DNA and supports normal neuronal development and synaptic function; loss-of-function mutations in the MECP2 gene are the primary cause of Rett syndrome, which is why antibodies targeting this protein are widely used in neurodevelopmental and neurological research.

The reagent is supplied as 100 µl of unconjugated IgG and is validated for western blot analysis of cell and tissue lysates, immunohistochemistry on fixed sections, and flow cytometry staining. The polyclonal format allows recognition of multiple epitopes on the target, which can be useful when probing post-translational variants or partially degraded samples. The antibody detects human MECP2 and is generated by standard rabbit immunization, providing a flexible reagent for protein-level studies.

Researchers commonly apply anti-MECP2 antibodies to map expression across neuronal populations, investigate X-linked neurodevelopmental disorders, and characterize MECP2 distribution in patient-derived samples and disease model systems. Reagents may be stored refrigerated for routine use, with aliquots recommended to limit freeze-thaw cycles when working with small volumes.