Anti-MECP2 Antibody

MECP2 (Methyl-CpG Binding Protein 2) is a chromatin-associated transcriptional regulator essential for neuronal development and synaptic function, with loss-of-function mutations in the MECP2 gene causally linked to Rett syndrome and other neurodevelopmental disorders. This polyclonal reagent from Antibodies.com is raised in rabbit and validated for detection of endogenous MECP2 protein in human, mouse, and rat samples, supporting cross-species studies in neuroscience, epigenetics, and rare-disease research workflows.

The antibody is validated for Western blot, immunohistochemistry, and immunofluorescence, enabling laboratories to characterize MECP2 expression levels and subcellular localization across multiple platforms using a single reagent. Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot, the unconjugated format permits flexible pairing with secondary antibodies and custom detection chemistries such as fluorescent, chromogenic, or HRP-based systems.

The formulation supports storage at -20 °C with minimal freeze-thaw impact for long-term research use, and aliquoting on first thaw is recommended to preserve antibody activity across repeated experiments probing neuronal nuclear extracts or fixed brain tissue sections.