Anti-MDM4 Antibody

This polyclonal antibody from Antibodies.com is raised in rabbit against MDM4 (also called MDMX or HDMX), a negative regulator of the p53 tumor suppressor pathway that binds p53's transactivation domain and dampens p53-driven transcription. The unconjugated IgG reagent is supplied at 100 µl and validated for Western blot detection of the human protein in cell lysates and tumor samples.

MDM4 is amplified or overexpressed in cancers that retain wild-type TP53, including retinoblastoma and subsets of breast carcinoma and melanoma, making reliable detection reagents valuable for cancer biology research. Use this reagent to probe MDM4 expression, isoform balance, and regulatory interactions in p53 signaling and DNA damage response studies. Aliquot on arrival and store refrigerated to preserve antibody activity across repeated experiments; the polyclonal format offers broader epitope coverage than monoclonal alternatives for detecting both full-length and truncated MDM4 isoforms.