Anti-MDM2 (phospho S166) Antibody

Raised in rabbit and affinity-purified as an IgG polyclonal, this Antibodies.com reagent detects MDM2 only when serine 166 is phosphorylated. The unconjugated reagent ships as 100 µl in a single-use vial and is validated across Western blot, immunohistochemistry on paraffin-embedded tissue, and immunofluorescence imaging workflows. Serine 166 sits within an ATM kinase substrate motif, so the antibody discriminates the DNA-damage-induced phospho-S166 form of MDM2 from the total pool, a distinction that matters for p53 turnover studies and apoptosis pathway research. Human MDM2 is the verified reactive species, and the IgG isotype permits flexible secondary antibody pairing. For research use only; aliquot upon receipt and store refrigerated in single-use portions to limit freeze-thaw loss.