Anti-MDM2 Antibody

This polyclonal antibody from Antibodies.com targets the MDM2 oncoprotein, an E3 ubiquitin ligase that negatively regulates p53 tumor suppressor activity in cells. Produced in rabbit hosts and supplied as an unconjugated 100 µl liquid aliquot, the reagent is validated for Western blot and ELISA workflows using human samples.

MDM2 overexpression and gene amplification are frequently documented in sarcomas, gliomas, and breast carcinomas, so reliable detection of the protein is central to studies of p53 pathway dysregulation, cell cycle control, and apoptosis. In Western blot, the antibody enables identification of MDM2 bands in cell lysates, while ELISA compatibility supports quantitative measurements in tissue-derived and cell-derived samples. The unconjugated format allows researchers to pair the antibody with HRP, fluorophore, or other secondary detection chemistries according to their preferred workflow.

For handling, aliquot upon receipt and store frozen, avoiding repeated freeze-thaw cycles to preserve antibody activity. This reagent is intended for research use only.