Anti-MDH2 Antibody

The polyclonal rabbit reagent from Antibodies.com is raised against MDH2, the mitochondrial isoform of malate dehydrogenase that catalyzes the reversible NAD+/NADH-dependent interconversion of malate and oxaloacetate within the mitochondrial matrix. Supplied as 100 ul of unconjugated antibody, it is suited to western blot and immunohistochemistry workflows on human samples and supports studies of cancer metabolism, mitochondrial bioenergetics, and the malate-aspartate shuttle. MDH2 is frequently used as a marker of mitochondrial matrix content in research on TCA cycle flux, oxidative stress responses, and the metabolic reprogramming characteristic of tumor cells. The polyclonal format allows recognition of multiple epitopes on the target, which can be useful when probing denatured lysates or fixed tissue sections where monoclonal reagents may drop signal. The reagent is a rabbit host IgG preparation intended for research use only.