Anti-MCPH1 Antibody

Rabbit polyclonal antibody raised against human MCPH1 (Microcephalin 1), a nuclear DNA damage response regulator whose loss-of-function mutations cause autosomal recessive primary microcephaly. Supplied as 100 µl of unconjugated antiserum, the reagent is validated for western blot and immunohistochemistry on human samples. MCPH1 coordinates the G2/M checkpoint through interactions with CHK1 and BRCA1, and it contributes to chromosome condensation, homologous recombination repair, and telomere maintenance. Researchers use this reagent to study microcephaly pathogenesis, cell cycle control, and tumor biology, since the protein is frequently downregulated across multiple cancer types. Provided by Antibodies.com for research use only, it supports workflows in neurodevelopmental genetics, DNA repair pathway analysis, and genome stability investigations.