Anti-MCM8 Antibody

Affinity-purified polyclonal reagent from Antibodies.com targeting MCM8, a minichromosome maintenance family member recruited to stalled replication forks and required for homologous recombination–mediated DNA double-strand break repair in dividing cells. The immunogen corresponds to a region of human MCM8, and the antibody has been validated for Western blot detection of the endogenous ~95 kDa protein in lysates prepared from human, mouse, and rat cell lines and tissues, showing confirmed reactivity across all three species.

Provided as 200 µL of unconjugated rabbit IgG in a single vial, the reagent is shipped refrigerated and should be aliquoted upon arrival to limit freeze–thaw cycles and preserve long-term activity for repeat probing of PVDF or nitrocellulose membranes. Researchers studying DNA replication stress, genome stability, crossover resolution during meiosis, or the contribution of MCM8 loss-of-function variants to primary ovarian insufficiency and hormone-driven cancers use this reagent to monitor protein expression, assess chromatin recruitment, and compare wild-type versus mutant alleles. The unconjugated format also allows flexible pairing with custom chemiluminescent or infrared secondary antibodies.