Anti-MCM8 Antibody

This rabbit polyclonal IgG antibody targets MCM8 (Minichromosome Maintenance 8 Homologous Recombination Repair Factor), a helicase-domain protein recruited to stalled replication forks and DNA double-strand breaks, where it partners with MCM9 to drive homologous recombination repair. From Antibodies.com as an unconjugated primary reagent, the antibody is supplied at 100 µl per vial and validated for Western Blot detection of endogenous MCM8 in lysates from human, mouse, and rat samples, supporting studies of DNA damage response, replication stress, and genome stability pathways. The polyclonal format presents multiple MCM8 epitopes, which improves signal capture when target expression is low and aids resolution of full-length versus truncated isoforms. Published work links MCM8 loss-of-function to homologous recombination deficiency and to germline predisposition syndromes, so a reagent that resolves MCM8 across standard cell-line and tissue models is useful for both basic repair biology and translational work on DNA repair-deficient tumour contexts.