Anti-MCM5 Antibody

MCM5 (Minichromosome Maintenance Complex Component 5) is a subunit of the MCM2-7 hexameric helicase complex that primes origins of replication during G1 phase and supports replication fork progression through S phase. This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes endogenous MCM5 in human, mouse, and rat specimens and is validated for western blot, immunohistochemistry, and immunofluorescence workflows.

Investigators apply anti-MCM5 reagents to map DNA replication licensing, characterize proliferating cell populations in tissue sections, and analyze G1/S checkpoint function. Elevated MCM5 levels are studied as a proliferation biomarker in oncology, with published work on cervical, breast, colorectal, and urothelial carcinomas as well as glioma, and as a candidate non-invasive marker in urine cytology for bladder cancer screening. The 100 µL format supports both small-scale optimization and larger IHC or immunofluorescence panels, and storage at -20 °C with freeze-thaw minimization preserves lot-to-lot consistency for longitudinal studies.