Anti-MCL1 Antibody

Raised in rabbit against the human MCL1 protein, this unconjugated polyclonal antibody from Antibodies.com is supplied as a 100 µl vial of reagent suited to western blot and immunohistochemistry workflows.

MCL1 (Myeloid Cell Leukemia 1) is a BCL-2 family anti-apoptotic factor anchored at the mitochondrial outer membrane, where it restrains pro-apoptotic BAX and BAK activation and sustains survival in hematopoietic, cardiac, and neuronal populations. The reagent recognizes endogenous MCL1 in human, mouse, and rat samples, enabling translational studies on chemoresistance, lymphoma biology, and stress-induced apoptosis. Researchers commonly use it to monitor MCL1 stabilization and turnover, a process tightly regulated through proteasomal degradation that is frequently dysregulated in multiple myeloma, acute myeloid leukemia, and various solid tumor contexts. For handling, the antibody should be aliquoted and stored frozen, with limited freeze-thaw cycles to preserve reactivity across extended experimental timelines.