Anti-Mcl-1 Antibody

Mcl-1 (Myeloid Cell Leukemia 1) is a key anti-apoptotic member of the Bcl-2 family that regulates mitochondrial outer membrane permeabilization and cell survival signaling. This rabbit polyclonal antibody from Antibodies.com is raised against Mcl-1 and validated for Western blot, immunohistochemistry, and ELISA workflows across Human, Mouse, and Rat samples, giving laboratories a single reagent for cross-species apoptosis studies.

Supplied as 50 µl of unconjugated antisera, the antibody is suited to detecting the approximately 37 kDa Mcl-1 protein in cell lysates and tissue sections, supporting oncology, chemotherapy-resistance, and mitochondrial biology research where Mcl-1 overexpression is a frequent finding in lymphoid malignancies and many solid tumors. The polyclonal host format increases the likelihood of recognizing multiple epitopes on the target, which is helpful when studying full-length Mcl-1 alongside its shorter isoforms and truncated cleavage products generated during cellular stress signaling. Researchers typically aliquot the stock upon arrival to limit freeze-thaw cycles and protect antibody activity during long-term storage.