Anti-Mcl-1 Antibody

An unconjugated rabbit polyclonal reagent supplied in a 100 µl vial volume, this Antibodies.com primary antibody targets the anti-apoptotic Bcl-2 family protein Mcl-1 (Myeloid Cell Leukemia 1) and is validated for western blot (WB), immunohistochemistry (IHC), and ELISA across human, mouse, and rat samples. Mcl-1 localizes to the mitochondrial outer membrane, where it sequesters pro-apoptotic effectors such as Bak and Bax to sustain cell survival, and its dysregulation is a recurring theme in lymphoma, leukemia, and solid tumor biology. The polyclonal format delivers recognition of multiple epitopes on the Mcl1 target, supporting clear bands in immunoblotting of whole-cell lysates, distinct staining of formalin-fixed paraffin-embedded tissue sections, and reproducible signal in ELISA-based quantification. Researchers studying programmed cell death, mitochondrial apoptosis pathways, and mechanisms of chemoresistance use this reagent to monitor endogenous Mcl-1 expression and to investigate how Bcl-2 family balance shapes treatment response.