Anti-MCC Antibody

This polyclonal reagent from Antibodies.com is raised in rabbit against the MCC (Mutated in Colorectal Cancer) tumor suppressor protein and is supplied as 50 µl of unconjugated IgG for use in immunohistochemistry workflows on formalin-fixed, paraffin-embedded tissue. The antibody recognizes the human MCC antigen and is referenced across colorectal cancer research, where MCC loss-of-function mutations contribute to aberrant Wnt/β-catenin signaling and disrupted intestinal epithelial differentiation.

Investigators apply it to map MCC expression across normal mucosa, adenomatous polyps, and carcinoma specimens, and to explore MCC involvement in other epithelial malignancies including gastric and pancreatic tumors. As an unconjugated primary antibody, it pairs with enzyme- or fluorophore-labeled secondary reagents, enabling chromogenic DAB staining and fluorescence detection protocols alike. Refrigerated storage preserves activity for routine laboratory use, and the polyclonal format offers multi-epitope recognition that helps detection when target expression is reduced.