Anti-MCAM Antibody

The MCAM antigen, also known as CD146, is a transmembrane immunoglobulin superfamily glycoprotein of approximately 113 kDa, originally identified on melanoma cells and now widely used as a marker of endothelial activation, angiogenesis, mesenchymal stem cells, and several metastatic tumor types. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against MCAM and validated for Western blot and immunohistochemistry workflows on human samples, where it can be applied to studies of angiogenic vasculature, pericyte coverage, vascular smooth muscle, and MCAM-positive tumor subpopulations in formalin-fixed paraffin-embedded tissue sections and cell lysate preparations. Supplied as a 100 µL aliquot in vial format, the antibody supports research into tumor invasion, neovascularization, and stem cell biology, with reactivity confirmed against the human MCAM protein.