Anti-MCAM Antibody

This rabbit polyclonal IgG antibody targets Melanoma Cell Adhesion Molecule (MCAM), a 113 kDa transmembrane glycoprotein also known as CD146 or MUC18. Produced by Antibodies.com as a primary reagent, it is supplied as 50 µl of unconjugated antibody in a vial, intended for western blot workflows on lysates derived from human, mouse, and rat samples.

MCAM/CD146 is widely used as a surface marker for endothelial cells, mesenchymal stem cells, and pericytes, and it has been studied in the context of melanoma invasion, tumor angiogenesis, and vascular remodeling. The antibody is validated for western blot detection of the target, supporting research in vascular biology, stem cell characterization, and oncology models. For handling, store the vial refrigerated at 4 °C for short-term use; for longer-term storage, aliquot the antibody and freeze at -20 °C to limit repeated freeze-thaw cycles of the solution.

Because the host species is rabbit and the reagent is polyclonal, it recognizes multiple epitopes on MCAM, which can be helpful when probing proteins that may show variation across human, mouse, and rat samples. Pair it with an anti-rabbit HRP or fluorescent secondary for chemiluminescent or imaged western blot readout. Cited reactivity covers human, mouse, and rat, and the unconjugated format provides flexibility in choosing a downstream label.