Anti-MC4R Antibody

This rabbit polyclonal antibody targets the melanocortin 4 receptor (MC4R), a G-protein coupled receptor that plays a central role in hypothalamic regulation of food intake, energy expenditure, and body weight. MC4R signaling is a frequent focus of obesity and metabolic disease research, and loss-of-function mutations in the MC4R gene are among the most common monogenic causes of severe early-onset obesity in humans.

The reagent is supplied by Antibodies.com as an unconjugated IgG in 200 µl volume, raised in rabbit and purified as a polyclonal preparation. It is validated for Western blot detection of MC4R in human, mouse, and rat samples, supporting translational studies that compare receptor expression across rodent models and patient-derived tissue.

Storage recommendations include keeping the vial at -20 °C in working aliquots to limit freeze-thaw cycles, with the antibody remaining suitable for downstream immunoblotting of membrane-associated GPCR proteins. Researchers investigating appetite circuits, leptin-melanocortin pathway cross-talk, and anti-obesity drug targets will find this reagent useful for probing MC4R protein levels in hypothalamic lysates and transfected cell lines.