Anti-MC4R Antibody

Melanocortin 4 receptor (MC4R) is a G-protein coupled receptor central to appetite regulation, energy homeostasis, and body weight control. Loss-of-function mutations in MC4R are the most common monogenic cause of human obesity, making this receptor a frequent target in metabolic disease research.

This unconjugated rabbit polyclonal reagent from Antibodies.com was raised against MC4R and is validated for Western blot detection across human, mouse, and rat samples. The IgG antibody is provided at 100 µl and binds the native melanocortin 4 receptor, supporting studies of hypothalamic signaling, feeding behavior, and downstream cAMP pathways.

Researchers apply this reagent to probe MC4R expression in neural tissue lysates, characterize mutant variants linked to severe early-onset obesity, and investigate peptide agonist and antagonist interactions relevant to obesity therapeutics. Refrigerate upon arrival; aliquot and freeze at -20°C for longer-term storage to limit freeze-thaw degradation.