Anti-MC1R Antibody

The Melanocortin 1 Receptor (MC1R) is a G protein-coupled receptor that regulates cAMP-driven melanogenesis in melanocytes and modulates pigmentation, UV-induced stress responses, and inflammatory signaling. This unconjugated IgG reagent from Antibodies.com is a rabbit polyclonal antibody validated for Western blot (WB) and immunohistochemistry (IHC) on human and mouse samples.

MC1R is widely studied in pigmentation genetics and melanoma research because loss-of-function variants are linked to red hair, fair complexion, freckling, and elevated cutaneous melanoma risk. Investigators use this reagent to compare receptor expression across melanocyte cultures, melanoma cell models, and skin tissue sections. The polyclonal format offers multi-epitope recognition useful when probing variant receptors in tissue.

The antibody is supplied as a 50 µl vial of unconjugated stock. Aliquot upon receipt, protect from light, and store refrigerated; limit freeze-thaw cycles to preserve activity across repeated experiments.