Anti-MAX Antibody

Transcription factor research into the MYC-MAX-MAD regulatory network depends on reliable antibodies against MAX, and this polyclonal reagent from Antibodies.com meets that need as an unconjugated rabbit IgG preparation supplied in a 100 µl vial. The antibody recognizes the full-length MAX protein, a basic-helix-loop-helix-leucine zipper factor that heterodimerizes with MYC, MNT, MXD1, and MXI1 to either activate or repress transcription at E-box sites, and it is validated for Western blot detection across human, mouse, and rat samples as well as for immunofluorescence staining of cultured cells and tissue sections where the nuclear localization of MAX can be visualized directly. Because MAX is expressed in essentially every proliferating cell type, the reagent is widely used to study growth control, differentiation, and the dysregulation of MYC-MAX signaling that drives a substantial fraction of human tumors; it is also useful as a normalization control when comparing MYC versus MAD family expression in matched lysates. Storage should follow standard polyclonal antibody practice: refrigerate the original vial, aliquot on first thaw, and protect from light.