Anti-MASP1 Antibody

Raised in rabbits and affinity-purified, this unconjugated polyclonal IgG reagent recognizes endogenous MASP1 (mannan-binding lectin serine protease 1), a key serine protease that cleaves complement components C2 and C4 and initiates the lectin pathway of innate immunity. Antibodies.com provides 100 µL of ready-to-use primary antibody validated for Western blot detection of the endogenous target in human, mouse, and rat samples, making it suitable for complement-pathway studies spanning innate immunity, infection, and inflammatory disease models. The product is supplied as a liquid aliquot; store at -20 °C in single-use portions to avoid repeated freeze-thaw cycles, and protect from light if working dilutions are prepared. Common applications include immunoblotting of liver lysates, supporting experiments on lectin pathway activation, opsonization-independent complement triggering, and crosstalk between MASP1/MASP2 and the MBL complex. Each lot is quality-controlled to confirm specificity for MASP1 and minimal cross-reactivity with related proteases such as MASP2, C1r, and C1s, helping researchers generate reproducible bands in studies of lectin-pathway-driven inflammation.