Anti-MAPKAPK3 Antibody

Rabbit polyclonal antibody targeting MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3), a serine/threonine kinase belonging to the calcium/calmodulin-dependent kinase family. This unconjugated IgG reagent is supplied by Antibodies.com as a 100 µL aliquot and is validated for Western blot and immunofluorescence workflows across human, mouse, and rat samples.

MAPKAPK3 functions as a downstream substrate of the p38 and ERK MAP kinase pathways, contributing to stress-activated signalling, inflammatory cascades, and translational control through phosphorylation of substrates such as Hsp27 and TSC2. The polyclonal format provides recognition of multiple epitopes on the kinase, which is useful for confirming expression patterns in cell lysates and fixed specimens. The unconjugated format allows researchers to pair the antibody with their own detection chemistry, including fluorophore or HRP labelling, depending on the downstream assay.

Recommended handling is to refrigerate the antibody and to prepare small aliquots to limit repeated freeze-thaw cycles of the stock. Researchers frequently apply this reagent in basic research aimed at dissecting MAPK signalling crosstalk, cytoskeletal regulation following cellular stress, and mechanisms of cytokine-driven inflammation.