Anti-MAPK3 Antibody

MAPK3, also known as ERK1 (Extracellular signal-regulated kinase 1), is a serine/threonine kinase that sits at the core of the canonical Ras-Raf-MEK-ERK signal transduction cascade, where it phosphorylates downstream substrates including transcription factors and cytoskeletal regulators to control cell proliferation, differentiation, and survival.

This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against MAPK3 and validated for Western Blot (WB) and Immunohistochemistry (IHC) workflows on human, mouse, and rat samples, supporting pathway-focused studies of growth factor signaling, neuronal plasticity, oncogenic transformation, and tissue-level localization of ERK1.

Supplied as a 100 µl liquid aliquot without a conjugated reporter, the antibody drops easily into chromogenic, fluorescent, or chemiluminescent detection schemes, and is appropriate for probing total MAPK3 abundance in cell or tissue lysates and for mapping expression patterns in formalin-fixed paraffin-embedded sections. Researchers investigating MAPK pathway deregulation in cancer, developmental signaling, or inflammatory responses commonly use ERK1/MAPK3 as a normalization reference alongside phospho-ERK readouts, making this reagent a practical anchor for both mechanistic and translational projects.