Anti-MAPK1 Antibody

The MAPK1 protein, also known as ERK2, is a 41-44 kDa serine/threonine kinase central to the RAF-MEK-ERK signal transduction cascade that relays extracellular mitogenic cues into intracellular responses governing proliferation, differentiation, and survival. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against MAPK1 and validated for western blot, immunohistochemistry, and immunofluorescence workflows using human, mouse, and rat samples, supporting pathway studies in oncology, neuroscience, and cardiovascular research. MAPK1 sits at the convergence of receptor tyrosine kinase, G-protein coupled receptor, and integrin signaling inputs, making reliable detection antibodies essential for dissecting downstream phosphorylation events and nuclear translocation of activated ERK. Supplied as 100 µl of polyclonal antiserum, this reagent enables detection of endogenous MAPK1 expression in whole-cell lysates, formalin-fixed tissue sections, and adherent cultured cells, and is commonly paired with phospho-specific ERK antibodies to monitor activation-state dynamics under basal or growth-factor-stimulated conditions.