Anti-MAP3K8 (Ab-400) Antibody

Generated in rabbit hosts, this polyclonal reagent from Antibodies.com recognizes MAP3K8 (also known as TPL2 or COT), a serine/threonine kinase positioned upstream of MEK, ERK, and JNK signaling and studied extensively in inflammatory and oncogenic pathways. The antibody is raised against a region centered on residue 400 of the MAP3K8 protein, a regulatory site whose phosphorylation state influences kinase activity and downstream NF-κB signaling.

Supplied as 100 µl of unconjugated, affinity-purified material, the reagent is validated for Western blot and immunohistochemistry workflows on human samples. Researchers use it to probe endogenous MAP3K8 expression and modification status in cell lysates and formalin-fixed tissue sections, supporting studies of T-cell receptor signaling, Toll-like receptor responses, and tumor biology. The polyclonal format broadens epitope coverage compared with monoclonal alternatives, which is helpful when working with post-translational modifications or low-abundance targets.

Each vial is shipped refrigerated; aliquoting upon arrival is recommended to limit freeze-thaw cycles and preserve antibody stability across multiple experiments.