Anti-MAP3K14 Antibody

Positioned at the apex of the non-canonical NF-κB signaling cascade, MAP3K14 (also known as NIK, NF-κB-inducing kinase) is a serine/threonine kinase that regulates lymphoid organogenesis, B-cell maturation, and inflammatory signal transduction. This rabbit polyclonal IgG reagent from Antibodies.com is raised against MAP3K14 and supplied in a 50 µl vial sized for routine western blot and immunohistochemistry workflows. The antibody recognizes human, mouse, and rat orthologs, supporting cross-species studies of non-canonical NF-κB pathway activity in tumor, immune, and fibrosis models. Researchers apply it to probe NIK expression and proteasome-dependent processing in lymphoma, multiple myeloma, and solid tumor specimens, as well as in normal lymphoid tissues such as spleen and thymus. The polyclonal format recognizes multiple epitopes on MAP3K14, which is useful for monitoring the cleavage that converts full-length NIK into its active C-terminal fragment during signal-driven pathway activation. Shipped at 4°C for short-term transit; aliquot and store at -20°C, avoiding repeated freeze-thaw cycles. For research use only.