Anti-MAP2K4 (phospho T261) Antibody - Identical to Abcam (ab194820)

A polyclonal antibody raised in rabbit that specifically recognizes MAP2K4 only when phosphorylated at threonine 261. MAP2K4, also known as MKK4 or SEK1, sits upstream of the JNK and p38 MAPK cascades and is itself modulated by upstream kinases during cellular stress and cytokine signaling. The phospho-T261 site has been linked to negative feedback regulation and altered kinase activity following stress stimuli, making site-specific detection valuable for studies of signaling dynamics in oncology, neurodegeneration, and inflammation research.

From Antibodies.com, this unconjugated IgG reagent is supplied as 100 µl of polyclonal serum and is validated for immunohistochemistry (IHC) and immunofluorescence (IF) on human, mouse, and rat samples. Because it does not detect the unphosphorylated form, the antibody allows researchers to follow JNK pathway activation in fixed tissue sections and cultured cells, supporting studies of apoptosis, inflammation, and cellular stress responses. Reagent formats and validation data align with the sequence of the reference antibody from Abcam, giving laboratories a reproducible option for phospho-MAP2K4 work. The reagent is intended for research use only.