Anti-MAP2K4 (phospho S80) Antibody - Identical to Abcam (ab39403)

This rabbit polyclonal antibody from Antibodies.com specifically detects MAP2K4 when phosphorylated at serine 80 (phospho S80), a regulatory site on the dual-specificity kinase also known as MKK4, JNKK1, or SEK1. The reagent is supplied as 200 µl of unconjugated IgG, validated for Western blot, immunohistochemistry, and immunofluorescence workflows, and it cross-reacts with human, mouse, and rat samples. The phospho-S80 mark is generated by upstream MAP3K signaling and serves as a direct readout of activation through the JNK and p38 MAPK cascades, pathways implicated in cellular stress response, apoptosis, cytokine signaling, and tumor progression. The antibody is commonly used to monitor kinase activation in cell lysates, tissue sections, and fixed cells, and it is referenced as identical in performance to the Abcam ab39403 reagent, a widely cited tool in signal-transduction research. Polyclonal rabbit IgG provides broad epitope coverage around the phospho-S80 motif, and the unconjugated format supports flexible downstream detection with secondary antibodies of the researcher's choice. For long-term storage, freeze at -20 °C in working aliquots and avoid repeated freeze-thaw cycles to preserve activity.